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1

Improving Risk Assessment: Research Opportunities in Dose Response Modeling to Improve Risk Assessment

Zeise, Lauren, Hattis, Dale, Andersen, Mel, Bailer, A. John, Bayard, Steve, Chen, Chao, Clewell, Harvey, Conolly, Rory, Crump, Kenny, Dunson, David

Journal:

Human and Ecological Risk Assessment An International Journal

Year:

2002

Language:

english

File:

PDF, 212 KB

english, 2002

2

An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane

Richard D. Storer, Rory B. Conolly

Journal:

Toxicology and Applied Pharmacology

Year:

1985

Language:

english

File:

PDF, 943 KB

english, 1985

3

Dose-dependent transitions in mechanisms of toxicity: case studies

William Slikker Jr., Melvin E. Andersen, Matthew S. Bogdanffy, James S. Bus, Steven D. Cohen, Rory B. Conolly, Raymond M. David, Nancy G. Doerrer, David C. Dorman, David W. Gaylor, Dale Hattis, John M

Journal:

Toxicology and Applied Pharmacology

Year:

2004

Language:

english

File:

PDF, 2.52 MB

english, 2004

4

Dose-dependent transitions in mechanisms of toxicity

William Slikker Jr., Melvin E. Andersen, Matthew S. Bogdanffy, James S. Bus, Steven D. Cohen, Rory B. Conolly, Raymond M. David, Nancy G. Doerrer, David C. Dorman, David W. Gaylor, Dale Hattis, John M

Journal:

Toxicology and Applied Pharmacology

Year:

2004

Language:

english

File:

PDF, 421 KB

english, 2004

5

Uncertainties in estimating health risks associated with exposure to ionising radiation

Julian Preston, R, Boice Jr, John D, Bertrand Brill, A, Chakraborty, Ranajit, Conolly, Rory, Owen Hoffman, F, Hornung, Richard W, Kocher, David C, Land, Charles E, Shore, Roy E, Woloschak, Gayle E

Journal:

Journal of Radiological Protection

Year:

2013

Language:

english

File:

PDF, 358 KB

english, 2013

6

Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment

Perkins, Edward J., Ashauer, Roman, Burgoon, Lyle, Conolly, Rory, Landesmann, Brigitte, Mackay, Cameron, Murphy, Cheryl A., Pollesch, Nathan, Wheeler, James R., Zupanic, Anze, Scholz, Stefan

Journal:

Environmental Toxicology and Chemistry

Year:

2019

Language:

english

File:

PDF, 1.06 MB

english, 2019

7

A quantitative source-to-outcome case study to demonstrate the integration of human health and ecological endpoints using the Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks

Hines, David E, Conolly, Rory B., Jarabek, Annie M

Journal:

Environmental Science & Technology

Year:

2019

Language:

english

File:

PDF, 846 KB

english, 2019

8

Mirex induces ornithine decarboxylase in female rat liver

Ashoke Mitra, Ira Richards, Kirk Kitchin, Rory Conolly, Dr Arun P. Kulkarni

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1990

Language:

english

File:

PDF, 524 KB

english, 1990

9

An in vivo-in vitro alkaline DNA unwinding assay for hepatic DNA damage: Comparison with the alkaline sucrose gradient centrifugation technique

Richard D. Storer, Rory B. Conolly

Journal:

Analytical Biochemistry

Year:

1984

Language:

english

File:

PDF, 799 KB

english, 1984

10

Biologically based mathematical simulation of cytotoxicity and mutation accumulation

Rory B. Conolly, Richard H. Reitz, Melvin E. Andersen

Journal:

Year:

1987

Language:

english

File:

PDF, 48 KB

english, 1987

11

Cancer and non-cancer risk assessment: not so different if you consider mechanisms

Rory B. Conolly

Journal:

Year:

1995

Language:

english

File:

PDF, 940 KB

english, 1995

12

The use of biologically based modeling in risk assessment

Journal:

Year:

2002

Language:

english

File:

PDF, 99 KB

english, 2002

13

Binary gene induction and protein expression in individual cells

Qiang Zhang, Melvin E Andersen, Rory B Conolly

Journal:

Theoretical Biology and Medical Modelling

Year:

2006

Language:

english

File:

PDF, 650 KB

english, 2006

14

Quantitative analysis of liver GST-P foci promoted by a chemical mixture of hexachlorobenzene and PCB 126: implication of size-dependent cellular growth kinetics

Yasong Lu, Manupat Lohitnavy, Micaela Reddy, Ornrat Lohitnavy, Elizabeth Eickman, Amanda Ashley, Lisa Gerjevic, Yihua Xu, Rory B. Conolly, Raymond S. H. Yang

Journal:

Archives of Toxicology

Year:

2008

Language:

english

File:

PDF, 1.64 MB

english, 2008

15

Mechanistic Computational Model of Ovarian Steroidogenesis to Predict Biochemical Responses to Endocrine Active Compounds

Michael S. Breen, Daniel L. Villeneuve, Miyuki Breen, Gerald T. Ankley, Rory B. Conolly

Journal:

Annals of Biomedical Engineering

Year:

2007

Language:

english

File:

PDF, 666 KB

english, 2007

16

Benchmark Dose Risk Assessment for Formaldehyde Using Airflow Modeling and a Single-Compartment, DNA-Protein Cross-Link Dosimetry Model to Estimate Human Equivalent Doses

Paul M. Schlosser, Patrick D. Lilly, Rory B. Conolly, Derek B. Janszen, Julie S. Kimbell

Journal:

Year:

2003

Language:

english

File:

PDF, 177 KB

english, 2003

17

An Improved Approximation to the Exact Solution of the Two-Stage Clonal Growth Model of Cancer

Harvey J. Clewell III, Dennis W. Quinn, Melvin E. Andersen, Rory B. Conolly

Journal:

Year:

1995

Language:

english

File:

PDF, 563 KB

english, 1995

18

Computer Simulation of Clonal Growth Cancer Models. I. Parameter Estimation Using an Iterative Absolute Bisection Algorithm

David A. Kramer, Rory B. Conolly

Journal:

Year:

1997

Language:

english

File:

PDF, 835 KB

english, 1997

19

Response to “Eyes Closed Simple, Intuitive, Statistically Sound, and Efficient Methods for Estimating Parameters of Clonal Growth Cancer Models”

Rory B. Conolly, David A. Kramer

Journal:

Year:

1999

Language:

english

File:

PDF, 269 KB

english, 1999

20

Response to the Letter to the Editor: “The Dose-Response Model for Dioxin”

Melvin E. Andersen, Rory B. Conolly

Journal:

Year:

1998

Language:

english

File:

PDF, 209 KB

english, 1998

21

Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode-of-Action-Based Cancer Risk Assessment for Chloroform

Kai H. Liao, Yu-Mei Tan, Rory B. Conolly, Susan J. Borghoff, Michael L. Gargas, Melvin E. Andersen, Harvey J. Clewell III

Journal:

Year:

2007

Language:

english

File:

PDF, 481 KB

english, 2007

22

Commentary on “Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment” by Krewski et al.

Rory B. Conolly

Journal:

Year:

2009

Language:

english

File:

PDF, 42 KB

english, 2009

23

Improving Predictive Modeling in Pediatric Drug Development: Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling

WILLIAM SLIKKER JR., JOHN F. YOUNG, RICHARD A. CORLEY, DAVID C. DORMAN, RORY B. CONOLLY, THOMAS B. KNUDSEN, BRIAN L. ERSTAD, RICHARD H. LUECKE, ELAINE M. FAUSTMAN, CHARLES TIMCHALK, DONALD R. MATTISON

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 180 KB

english, 2005

24

Acute hepatic injury by vinyl chloride in rats pretreated with phenobarbital

JAEGER, RUDOLPH J., REYNOLDS, EDWARD S., CONOLLY, RORY B., MOSLEN, MARY TREINEN, SZABO, SANDOR, MURPHY, SHELDON D.

Journal:

Year:

1974

File:

PDF, 626 KB

1974

25

Response to “Eyes Closed: Simple, Intuitive, Statistically Sound, and Efficient Methods for Estimating Parameters of Clonal Growth Cancer Models”

Rory B. Conolly, David A. Kramer

Journal:

Year:

1999

Language:

english

File:

PDF, 39 KB

english, 1999

26

Response to the Letter to the Editor: “The Dose-Response Model for Dioxin”

Melvin E. Andersen, Rory B. Conolly

Journal:

Year:

1998

Language:

english

File:

PDF, 222 KB

english, 1998

27

Comparison of Inhaled Formaldehyde Dosimetry Predictions with DNA–Protein Cross-Link Measurements in the Rat Nasal Passages

Elaine A. Cohen Hubal, Paul M. Schlosser, Rory B. Conolly, Julia S. Kimbell

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 220 KB

english, 1997

28

Hepatic Foci in Rats after Diethylnitrosamine Initiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotion: Evaluation of a Quantitative Two-Cell Model and of CYP 1A1/1A2 as a Dosimeter

Rory B. Conolly, Melvin E. Andersen

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 937 KB

english, 1997

29

Transplacental and Lactational Transfer of p,p′-DDE in Sprague–Dawley Rats

Li You, Evangelia Gazi, Shannon Archibeque-Engle, Mercedes Casanova, Rory B. Conolly, Henry d'A. Heck

Journal:

Toxicology and Applied Pharmacology

Year:

1999

Language:

english

File:

PDF, 147 KB

english, 1999

30

Development of a Physiologically Based Pharmacokinetic Model of 2-Methoxyethanol and 2-Methoxyacetic Acid Disposition in Pregnant Rats

Sean M. Hays, Barbara A. Elswick, Gregory M. Blumenthal, Frank Welsch, Rory B. Conolly, Michael L. Gargas

Journal:

Toxicology and Applied Pharmacology

Year:

2000

Language:

english

File:

PDF, 86 KB

english, 2000

31

A Physiologically Based Pharmacodynamic Analysis of Hepatic Foci within a Medium-Term Liver Bioassay Using Pentachlorobenzene as a Promoter and Diethylnitrosamine as an Initiator

Russell S. Thomas, Rory B. Conolly, Daniel L. Gustafson, Michael E. Long, Stephen A. Benjamin, Raymond S.H. Yang

Journal:

Toxicology and Applied Pharmacology

Year:

2000

Language:

english

File:

PDF, 167 KB

english, 2000

32

Effect of 18 HR fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats

Rudolph J. Jaeger, Rory B. Conolly, Sheldon D. Murphy

Journal:

Experimental and Molecular Pathology

Year:

1974

Language:

english

File:

PDF, 858 KB

english, 1974

33

Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling

Richard H. Reitz, Alan L. Mendrala, Richard A. Corley, John F. Quast, Michael L. Gargas, Melvin E. Andersen, Dee Ann Staats, Rory B. Conolly

Journal:

Toxicology and Applied Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.46 MB

english, 1990

34

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropyfluorophosphate

Jeffery M. Gearhart, Gary W. Jepson, Harvey J. Clewell III, Melvin E. Andersen, Rory B. Conolly

Journal:

Toxicology and Applied Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.26 MB

english, 1990

35

Ototoxicity of toluene in rats

Michael J. Sullivan, Kyle E. Rarey, Rory B. Conolly

Journal:

Neurotoxicology and Teratology

Year:

1988

Language:

english

File:

PDF, 636 KB

english, 1988

36

Dose–response modeling in reproductive toxicology in the systems biology era

Melvin E. Andersen, Russell S. Thomas, Kevin W. Gaido, Rory B. Conolly

Journal:

Reproductive Toxicology

Year:

2005

Language:

english

File:

PDF, 365 KB

english, 2005

37

Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose–response curves

Rory B. Conolly, David W. Gaylor, Werner K. Lutz

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 278 KB

english, 2005

38

How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? — A workshop review

Elaina M. Kenyon, Walter T. Klimecki, Hisham El-Masri, Rory B. Conolly, Harvey J. Clewell, Barbara D. Beck

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 592 KB

english, 2008

39

New directions in incidence–dose modeling

Melvin E. Andersen, James E. Dennison, Russell S. Thomas, Rory B. Conolly

Journal:

Trends in Biotechnology

Year:

2005

Language:

english

File:

PDF, 162 KB

english, 2005

40

Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages

Julia S Kimbell, Elizabeth A Gross, Regina B Richardson, Rory B Conolly, Kevin T Morgan

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 380 KB

english, 1997

41

Apoptosis and cancer risk assessment

Thomas L. Goldsworthy, Rory B. Conolly, Ronny Fransson-Steen

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1996

Language:

english

File:

PDF, 1.64 MB

english, 1996

42

Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin

Qiang Zhang, Sudin Bhattacharya, Douglas E Kline, Robert B Crawford, Rory B Conolly, Russell S Thomas, Norbert E Kaminski, Melvin E Andersen

Journal:

BMC Systems Biology

Year:

2010

Language:

english

File:

PDF, 2.76 MB

english, 2010

43

Improvements in Quantitative Noncancer Risk Assessment: Sponsored by the Risk Assessment Specialty Section of the Society of Toxicology

Barbara D. Beck, Rory B. Conolly, Michael L. Dourson, Daniel Guth, Dale Hattis, Carole Kimmel, Steven C. Lewis

Journal:

Fundamental and Applied Toxicology

Year:

1993

File:

PDF, 843 KB

1993

44

Relationship between Hepatocyte Necrosis, Proliferation, and Initiation Induced by Diethylnitrosamine in the Male F344 Rat

Michiyuki Kato, James A. Popp, Rory B. Conolly, Russell C. Cattley

Journal:

Fundamental and Applied Toxicology

Year:

1993

File:

PDF, 444 KB

1993

45

Development of a Mechanism-Based Dosimetry Model for 2,4,4-Trimethyl-2-pentanol-Induced α2u-Globulin Nephropathy in Male Fischer 344 Rats

Susan J. Borghoff, Michael L. Gargas, Melvin E. Andersen, Rory B. Conolly

Journal:

Fundamental and Applied Toxicology

Year:

1995

File:

PDF, 735 KB

1995

46

A 90-Day Chloroform Inhalation Study in Female and Male B6C3F1Mice: Implications for Cancer Risk Assessment

Jeffrey L. Larson, Michael V. Templin, Douglas C. Wolf, Keith C. Jamison, Joel R. Leininger, Stephane Méry, Kevin T. Morgan, Brian A. Wong, Rory B. Conolly, Byron E. Butterworth

Journal:

Fundamental and Applied Toxicology

Year:

1996

Language:

english

File:

PDF, 273 KB

english, 1996

47

DNA–Protein Cross-Links (DPX) and Cell Proliferation in B6C3F1Mice but Not Syrian Golden Hamsters Exposed to Dichloromethane: Pharmacokinetics and Risk Assessment with DPX as Dosimeter

Mercedes Casanova, Rory B. Conolly, Henry d’A. Heck

Journal:

Fundamental and Applied Toxicology

Year:

1996

Language:

english

File:

PDF, 246 KB

english, 1996

48

Support of Science-Based Decisions Concerning the Evaluation of the Toxicology of Mixtures: A New Beginning

Linda Teuschler, James Klaunig, Ed Carney, Janice Chambers, Rory Conolly, Chris Gennings, John Giesy, Richard Hertzberg, Curtis Klaassen, Ralph Kodell, Dennis Paustenbach, Raymond Yang

Journal:

Regulatory Toxicology and Pharmacology

Year:

2002

Language:

english

File:

PDF, 84 KB

english, 2002

49

A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments

Byron E. Butterworth, Rory B. Conolly, Kevin T. Morgan

Journal:

Year:

1995

Language:

english

File:

PDF, 1.95 MB

english, 1995

50

Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action

Gerald T. Ankley, David C. Bencic, Michael S. Breen, Timothy W. Collette, Rory B. Conolly, Nancy D. Denslow, Stephen W. Edwards, Drew R. Ekman, Natalia Garcia-Reyero, Kathleen M. Jensen, James M. Lazo

Journal:

Aquatic Toxicology

Year:

2009

Language:

english

File:

PDF, 1.16 MB

english, 2009

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